Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 930
Gene Symbol: CD19
CD19
0.100 Biomarker disease BEFREE Tisagenlecleucel, a CD19-specific autologous chimeric antigen receptor (CAR)-T cell therapy, is efficacious for the treatment of relapsed/refractory B-cell precursor acute lymphoblastic leukemia and diffuse large B-cell lymphoma. 31837735 2019
Entrez Id: 613
Gene Symbol: BCR
BCR
0.500 Biomarker disease BEFREE Molecular detection of the <i>BCR-ABL1</i> fusion transcripts is necessary for the genetic confirmation of a chronic myeloid leukemia diagnosis and for the risk classification of acute lymphoblastic leukemia. 31817063 2019
Entrez Id: 255738
Gene Symbol: PCSK9
PCSK9
0.010 Biomarker disease BEFREE PCSK9 interferes with LDL metabolism and causes dyslipidemias in hematological malignancies particularly acute lymphoblastic leukemia. 31812013 2020
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
0.080 AlteredExpression disease BEFREE Ghrelin induces autophagy and CXCR4 expression via the SIRT1/AMPK axis in lymphoblastic leukemia cell lines. 31809874 2020
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.020 AlteredExpression disease BEFREE Ghrelin induces autophagy and CXCR4 expression via the SIRT1/AMPK axis in lymphoblastic leukemia cell lines. 31809874 2020
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE RAS and TP53 can predict survival in adults with T-cell lymphoblastic leukemia treated with hyper-CVAD. 31804006 2020
Entrez Id: 930
Gene Symbol: CD19
CD19
0.100 Biomarker disease BEFREE Mechanisms of Relapse After CD19 CAR T-Cell Therapy for Acute Lymphoblastic Leukemia and Its Prevention and Treatment Strategies. 31798590 2019
Entrez Id: 374569
Gene Symbol: ASPG
ASPG
0.100 Biomarker disease BEFREE Asparaginase-Associated Pancreatitis in Acute Lymphoblastic Leukemia: Results From the NOPHO ALL2008 Treatment of Patients 1-45 Years of Age. 31770057 2020
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.020 GeneticVariation disease BEFREE IL-35 and IL-18 Serum Levels in Children With Acute Lymphoblastic Leukemia: The Relationship With Prognostic Factors. 31764513 2019
Entrez Id: 3131
Gene Symbol: HLF
HLF
0.400 Biomarker disease BEFREE The histone acetyltransferase EP300 regulates TCF3-HLF, which promotes acute lymphoblastic leukemia. 31757791 2020
Entrez Id: 8301
Gene Symbol: PICALM
PICALM
0.040 AlteredExpression disease BEFREE Molecular and phenotypic characterization of an early T-cell precursor acute lymphoblastic lymphoma harboring PICALM-MLLT10 fusion with aberrant expression of B-cell antigens. 31739126 2020
Entrez Id: 3131
Gene Symbol: HLF
HLF
0.400 AlteredExpression disease BEFREE The chimeric transcription factor TCF3-HLF defines an incurable acute lymphoblastic leukemia subtype. 31735627 2019
Entrez Id: 4582
Gene Symbol: MUC1
MUC1
0.010 Biomarker disease BEFREE Blinatumomab for Acute Lymphoblastic Leukemia: The First Bispecific T-Cell Engager Antibody to Be Approved by the EMA for Minimal Residual Disease. 31727793 2019
Entrez Id: 2108
Gene Symbol: ETFA
ETFA
0.010 Biomarker disease BEFREE Blinatumomab for Acute Lymphoblastic Leukemia: The First Bispecific T-Cell Engager Antibody to Be Approved by the EMA for Minimal Residual Disease. 31727793 2019
Entrez Id: 7465
Gene Symbol: WEE1
WEE1
0.020 Biomarker disease BEFREE Synergism Through WEE1 and CHK1 Inhibition in Acute Lymphoblastic Leukemia. 31717700 2019
Entrez Id: 1111
Gene Symbol: CHEK1
CHEK1
0.020 Biomarker disease BEFREE Synergism Through WEE1 and CHK1 Inhibition in Acute Lymphoblastic Leukemia. 31717700 2019
Entrez Id: 406947
Gene Symbol: MIR155
MIR155
0.040 AlteredExpression disease BEFREE In vitro knock-out of miR-155 suppresses leukemic and HCV virus loads in pediatric HCV-4-associated acute lymphoid leukemia: A promising target therapy. 31696995 2020
Entrez Id: 2309
Gene Symbol: FOXO3
FOXO3
0.030 GeneticVariation disease BEFREE FOXO3 gene polymorphisms influence the risk of acute lymphoblastic leukemia in Chinese children. 31691337 2020
Entrez Id: 3934
Gene Symbol: LCN2
LCN2
0.010 Biomarker disease BEFREE Serum neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for predicting high dose methotrexate associated acute kidney injury in children with acute lymphoblastic leukemia. 31676986 2020
Entrez Id: 1050
Gene Symbol: CEBPA
CEBPA
0.020 AlteredExpression disease BEFREE It may seem that CEBPA expression level itself has potentially no effect on arising and progression of acute lymphoblastic leukemia, although it is a matter that needs further investigation. 31666608 2019
Entrez Id: 55270
Gene Symbol: NUDT15
NUDT15
0.100 Biomarker disease BEFREE The Role of TPMT, ITPA, and NUDT15 Variants during Mercaptopurine Treatment of Swedish Pediatric Patients with Acute Lymphoblastic Leukemia. 31635813 2020
Entrez Id: 374569
Gene Symbol: ASPG
ASPG
0.100 AlteredExpression disease BEFREE Clinical decisions following implementation of asparaginase activity monitoring in pediatric patients with acute lymphoblastic leukemia: Experience from a single-center study. 31625674 2020
Entrez Id: 930
Gene Symbol: CD19
CD19
0.100 Biomarker disease BEFREE Currently, CD19-targeted CAR T-cell therapy is approved for relapsed/refractory diffuse large B-cell lymphoma and acute lymphoblastic leukemia. 31622496 2020
Entrez Id: 56950
Gene Symbol: SMYD2
SMYD2
0.010 AlteredExpression disease BEFREE Overexpression of SET and MYND domain-containing protein 2 (<i>SMYD2</i>) is associated with poor prognosis in pediatric B lineage acute lymphoblastic leukemia. 31612757 2020
Entrez Id: 374569
Gene Symbol: ASPG
ASPG
0.100 Biomarker disease BEFREE Asparaginase formulation impacts hypertriglyceridemia during therapy for acute lymphoblastic leukemia. 31612640 2020